Hepatitis C Virus Infection

Report Code: HC-R-17-152 | Page Numbers: 33

Freedom from injecting Interferon (IFN), treating major HCV genotypes WW and betting on vaccines could bring a sea of change in the treatment of HCV infection in the future. This year the first IFN-free drug options for HCV Genotype 2/3- Gilead?s Sofosbuvir/RBV (GS-7977, PDUFA Dec. 8, 2013) is expected to be approved and launched! By 2015 launch of Gilead?s Sofosbuvir/Ledipasvir (PhIII) and AbbVie/ Enanta?s (ABT-450r/ABT-472/ABT-333) should remove the need of IFN for GT1 genotype HCV patients as well!

Tapping the Bigger Market- ROW: Gilead is moving well towards offering the best treatment options to a broader HCV pt population WW. . Genotype 1 is common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 is found in Vietnam and other Southeast Asian countries. In India and Pakistan, genotype 3 is predominant, while genotype 4 is found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. A PAN genotype effective drug is what most companies are trying to sequester in their pipeline. This report comprehensively covers the current Standard of Care, its limitations and Future options for the treatment of HCV infection....

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Freedom from injecting Interferon (IFN), treating major HCV genotypes WW and betting on vaccines could bring a sea of change in the treatment of HCV infection in the future. This year the first IFN-free drug options for HCV Genotype 2/3- Gilead?s Sofosbuvir/RBV (GS-7977, PDUFA Dec. 8, 2013) is expected to be approved and launched! By 2015 launch of Gilead?s Sofosbuvir/Ledipasvir (PhIII) and AbbVie/ Enanta?s (ABT-450r/ABT-472/ABT-333) should remove the need of IFN for GT1 genotype HCV patients as well!

Tapping the Bigger Market- ROW: Gilead is moving well towards offering the best treatment options to a broader HCV pt population WW. . Genotype 1 is common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 is found in Vietnam and other Southeast Asian countries. In India and Pakistan, genotype 3 is predominant, while genotype 4 is found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. A PAN genotype effective drug is what most companies are trying to sequester in their pipeline. This report comprehensively covers the current Standard of Care, its limitations and Future options for the treatment of HCV infection.
1.Executive Summary
2.Progress in the Clinical Development of HCV drugs
.Noteworthy progress in the Oral IFN -Free combinations for Treatment of HCV
.Options for the most Challenging Patient Subtypes in HCV
.IFN intolerant and other Genotypes
.Hepatitis C Virus Prevalence in ROW
3.Competitive Landscape - IFN-Free drugs
.Gilead?s sofosbuvir/ ledipasvir
.AbbVie? ABT-450r/ABT-472/ABT-333
.Boehringer Ingelheim?s faldaprevir/BI 207127
.Medevir?s simeprevir
.Vertex?s VX-135
.Bristol Myers? daclatasvir/asunaprevir
.Merck- MK-5172/MK-8742
4.Market Dynamics- Present and Future
.Present- Launch of Protease Inhibitors: Sunset Sooner Than Expected.
.Future- the ?best-in-class IFN-free oral pill? for HCV
5.HCV Vaccines
.GlobeImmune
.Okairos
.ChronTech Pharma/ Inovio
.Transgene?s TG4040
.Profectus Biosciences? HCV vaccine
.Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
6.HCV-HIV Co infection
.Pricing
.Market share dynamics
7.ANNEXURE
.Key Milestones
.Table 1 - Data from IFN-free combinations
.Table 2 - Viral response in genotype-1 patients - IFN-combinations
.Key Abstract presented at AASLD ?13
Freedom from injecting Interferon (IFN), treating major HCV genotypes WW and betting on vaccines could bring a sea of change in the treatment of HCV infection in the future. This year the first IFN-free drug options for HCV Genotype 2/3- Gilead?s Sofosbuvir/RBV (GS-7977, PDUFA Dec. 8, 2013) is expected to be approved and launched! By 2015 launch of Gilead?s Sofosbuvir/Ledipasvir (PhIII) and AbbVie/ Enanta?s (ABT-450r/ABT-472/ABT-333) should remove the need of IFN for GT1 genotype HCV patients as well!

Tapping the Bigger Market- ROW: Gilead is moving well towards offering the best treatment options to a broader HCV pt population WW. . Genotype 1 is common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 is found in Vietnam and other Southeast Asian countries. In India and Pakistan, genotype 3 is predominant, while genotype 4 is found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. A PAN genotype effective drug is what most companies are trying to sequester in their pipeline. This report comprehensively covers the current Standard of Care, its limitations and Future options for the treatment of HCV infection.

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